The interesting thing about this compound is its smiles. Both O=n1ccccc1 and [O-][n-]1cccc1 represents this compound, well kind of the two forms of this compound. The interpretation of the two smiles are common caveats in many cheminformatics tools. Right now, CDK can only correctly parse the second form of smiles, not the first one. On the contrary, the smi2gif web service at UCSF can only convert the first smiles to a gif image. However, the image is really a direct representation of “O=n1cccc1” (show as below). http://chimeraservices.compbio.ucsf.edu/cgi-bin/smi2gif.cgi?smiles=O=n1ccccc1&width=200&height=200&bgcolor=whitePyridine-N-Oxide derivatives are inhibitory to HIV and SARS. Some members inhibit the HIV-1 reverse transcriptase, others act at the level of HIV gene expression.

  1. Balzarini J, Stevens M, De Clercq E et al. Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action. J Antimicrob Chemother 2005; 55: 135–8.
  2. Balzarini J, Keyaerts E, Vijgen L et al. Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture. J. Antimicrob. Chemother., March 1, 2006; 57(3): 472 – 481.
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